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UVLrx Therapeutics™

UVLrx™ In Anti-Aging Medicine

Feature

Inflammation TriggersTriggers ManifestationTherapeutic WavelengthMeasure
EnvironmentIntroduces Pathogens (Virus and Bacteria)365nm (UVA)Viral Load*
StressIncreased Cortisol Promotes NF-kB630nm (Visible Red)Cortisol Levels* Heart Rate Variability
mTORInhibits Akt Promotes NF-kB530nm (Visible Green)Immunoassay* (Akt protein kinase)

Natural Human Aging

Aging in humans is driven by cellular senescence which is the irreversible arrest of our cell’s lifecycle. This cycle is governed by the limited number of times a cell divides, eventually reaching the point where it no longer divides.

Several pathways drive cell senescence such as pathogens (viruses and bacteria), stress, and other naturally occurring elements in the body.

Impact of Therapeutic Wavelengths on Inflammation

365nm – UVA

Pathogen Deactivation *

  • Damaging and destroying viruses, bacteria and fungus in the blood
  • Inhibits binding and replication

530nm – Visible Green

Reduction of Inflammation *

  • Down-regulation in mTOR
  • Up-regulation of Protein Kinase B (Akt)

630nm – Visible Red

Reduction of Inflammation *

  • Inhibits drivers such as NF-kB and COX-2 involved in pro-inflammatory cytokines synthesis

Immune System Modulation *

  • Activation of Leukocytes and phagocytosis process
  • Promotes antigen and antibody production

* Pathogen Deactivation

  • Miley, G. The Knott Technique of ultraviolet blood irradiation in acute pyogenic infections. New York State Journal of Medicine. 1942: 38-46.Pathogen Deactivation
  • Miley, G. Efficacy of ultraviolet blood irradiation therapy and control of Staphylococcemias. American Journal of Surgery. 1942;64(3):313-322
  • Miley G, Christensen. Ultraviolet blood irradiation therapy: Further studies in acute infections. American Journal of Surgery. 1947;73(4):486-493

* Reduction of Inflammation

  • Lopes NH, et al. Cyclooxygenase-2 and vascular endothelial growth factor expression in 5-fluorouracil-induced oral mucositis in hamsters: evaluation of two low-intensity laser protocols. Support Care Cancer. 2009;17(11):1409-15.
  • Genot MT, et al. Low-level laser for prevention and therapy of oral mucositis induced by chemotherapy or radiotherapy. Curr Opin Oncol. 2005;17(3):236-40.
  • Lopes NN, et al. Effects of low-level laser therapy on collagen expression and neutrophil infiltrate in 5-fluorouracil-induced oral mucositis in hamsters. Lasers Surg Med. 2010;42(6):546-52
  • Siniukhin VN, Ianenko EK, Safanov RM, Khamaganova EG, Borisik VI. The effect of endovascular helium-neon laser therapy on the immune status of patients with acute calculous pyelonephritis. Urol Nefrol (Mosk). 1996 Nov-Dec;(6):9-11.
  • Ivaniuta OM, Dziublik AIa, Skopichenko VN. Optimal effectiveness of complex treatment of patients with chronic obstructive bronchitis by intravascular laser irradiation of blood. Probl Tuberk. 1992;(5-6):21-4.

* Immune System Modulation

  • Du be A, Bansal H, Gupta PK. Modulation of macrophage structure and function by low-level He-Ne laser irradiation. Photochem Photobiol Sci. 2003;2(8):851-5

* Reduction of Inflammation

  • Karu T. Ten Lectures on Basic Science of Laser Phototherapy. Gangesber, Sweden: Prima Books AB (2007)
  • Fukuzaki Y, Sugawara H, Yamanoha B, Kogure S. 532 nm Low-Power Laser Irradiation Recovers γ-Secretase Inhibitor-Mediated Cell Growth Suppression and Promotes Cell Proliferation via Akt Signaling. PLoS One. 2013 Aug 7;8(8)

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